Immunoglobulin A (IgA) is the most abundant antibody isotype in the mucosal immune system. Structurally, IgA in the mucosal surface is a polymeric structure, while serum IgA is monomeric. Most IgAs were generated by the gut and have effects in situ. Besides the function of immune exclusion as a nonspecific immune role, recent studies found it also played an important role in specific immunity and immunoregulation. Learn more: Other Functional Receptors